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Sidst opdateret: 16/11 2017
Lisbeth Birk Møller - Curriculum vitae and Publications

Research Interests

My main focus is Menkes disease, Dopa-Responisive dystonia and pain sensitivity. Identification of new disease causing genes, and the mechanisms taken place in the Usher protein network. My main focus is genotype/phenotype relations

Patents

Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

Patent number: US5891664
Publication date: 1999-04-06
Inventor: Danø K; Blasi F; Roldan AL; Cubellis MV; Masucci MT; Appella E; Schleuning W-D; Behrendt N; Rønne E; Kristensen P; Pöllänen J; Salonen E-M; Stephens RW; Tapiovaara H; Vaheri A; Møller LB; Ellis V; Lund LR; Ploug M; Pyke C; Patthy L
Applicant: Cancerforskningsfondet af 1989

Urokinase-type plasminogen activator receptor

Patent number: US6248712
Publication date: 2001-06-19
Inventor: Danø K; Blasi F; Roldan AL; Cubellis MV; Masucci MT; Appella E; Schleuning W-D; Behrendt N; Rønne E; Kristensen P; Pöllänen J; Salonen E-M; Stephens RW; Tapiovaara H; Vaheri A; Møller LB; Ellis V; Lund LR; Ploug M; Pyke C; Patthy L
Applicant: Cancerforskningsfondet af 1989

Education

1993     PhD degree, University of Copenhagen. Field: Molecular Biology
1987     Cand. Scient. In Biochemistry, University of Copenhagen. Field: immunology

Employment

2000

-

 

 Senior Scientist, Kennedy Center

1997

-

2000

 Scientist, Kennedy Center

1993

-

1997

 Research assistant, Department of neurology, H. Lundbeck A/S

1991

-

1993

 PhD student, Department of Microbiology, University of Copenhagen

1988

-

1990

 Research Fellow, Department of Microbiology, University of Copenhagen

Oral presentations
About 40 oral presentations at national and international meetings included invited speaker. The most recent are listed below.

2009 “Menkes disease” 41st Sandbjerg meeting on membran transport, Sandbjerg

2008 “Long-term follow-up of tetrahydrobiopterin treatment of a patient with severe 6- pyruvoyl-tetrahydropterin synthase deficiency” 1st Meeting of the Scandinavian Movement Disorder Society, Gothenburg

2008

“Molecular diagnosis of Menkes disease: Genotype-phenotype correlation"
4th International Conference om Metals and Genetics, Paris

2007 “Mutations in dopa-responsiv dystonia” PKU and BH4, Sendai, Japan

2006 ”Mutationer i Danske Wilson patienter” Dansk selskab for Medicinsk Genetik

Poster presentation

Author or co-author of at least 70 abstracts presented at international conferences.
 
Teaching and scientific supervision

2009 -  Project-adviser for Post-Doc Tina Skjørringe
2009 - Project-adviser for cand. Scient Saiqa Yasmeen

2008 - 2009

Project-adviser for cand. Scient Shzeena Dad

2005 Project-adviser for cand. Scient Saiqa Yasmeen
2004 Project-adviser for cand. Scient. Marianne Paulsen

2001 Project-adviser for cand. Scient Lena Poulsen
1995- 2009 Adviser for 7 students in Biochemistry/Biology/Human biology, and adviser for 5 PhD students (2 of the 5 are still PhD students)

2008-2009 Extern adviser and examiner at 3 Bachelor-projects at RUC

1991 and 1992 Instructor at the practice course "Spring course on eukaryotic molecular Biology" at University of Copenhagen

1986 Teacher at Hvidovre Sygeplejeskole (2 semesters in Chemistry/Biochemistry)
1986 Instructor at practice courses in Immunology at University of Copenhagen

1982-1985 Careers adviser in Chemistry and Biochemisty, University of Copenhagen (20 hours/week)

  
Publications (search using Møller LB and Birk-Møller L)

73.
Nasser A, Møller LB, Olesen JH, Konradsen LS, Andreasen JT.
Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin.
Neurosci Res. 2014 Sep 10. pii: S0168-0102(14)00191-6. doi: 10.1016/j.neures.2014.08.015. [Epub ahead of print]

72.
Nasser A, Møller LB.
GCH1 gene variants, tetrahydrobiopterin and pain.
Scand J Pain, Volume 5 (2), April 2014, 121–128


71.
Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U.
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.
J Clin Invest. 2014 Jun 9. doi: 10.1172/JCI73778. [Epub ahead of print]

70.
Yasmeen S, Lund K, De Paepe A, De Bie S, Heiberg A, Silva J, Martins M, Skjørringe T, Møller LB.
Occipital horn syndrome and classical Menkes syndrome caused by deep intronic mutations, leading to the activation of ATP7A pseudo-exon.
Eur J Hum Genet. 2014 Apr;22(4):517-21. doi: 10.1038/ejhg.2013.191. Epub 2013 Sep 4.

69.
Dad S, Ostergaard E, Wadt K, Lunding J, Eiberg H, Møller L.
Identification of novel locus at chromosome 3p12.3-q13.31 for autosomal recessive intellectual disability in a consanguineous family.
Clin Genet. 2014 Apr;85(4):390-2. doi: 10.1111/cge.12161. Epub 2013 Apr 29.

68.
Andersson M, Mattle D, Sitsel O, Klymchuk T, Nielsen AM, Møller LB, White SH, Nissen P,
Copper-transporting P-type ATPases use a unique ion-release pathway.
Gourdon P.Nat Struct Mol Biol. 2013 Dec 8. doi: 10.1038/nsmb.2721. [Epub ahead of print]

67.
Møller LB, Rea G, Yasmeen S, Skjørringe T, Thorborg SS, Morrison PJ, Donnelly DE.
A silent nucleotide substitution in the ATP7A gene in a child with Menkes disease.
Mol Genet Metab. 2013 Sep 24. pii: S1096-7192(13)00324-7. [Epub ahead of print]

66.
Yasmeen S, Lund K, De Paepe A, De Bie S, Heiberg A, Silva J, Martins M, Skjørringe T, Møller LB.
Occipital horn syndrome and classical Menkes syndrome caused by deep intronic mutations, leading to the activation of ATP7A pseudo-exon.
Eur J Hum Genet. 2013 Sep 4. doi: 10.1038/ejhg.2013.191. [Epub ahead of print]

65.
Nasser A, Bjerrum OJ, Heegaard AM, Møller AT, Larsen M, Dalbøge LS, Dupont E, Jensen TS, Møller LB.
Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
Mol Pain. 2013 Feb 19;9(1):5. [Epub ahead of print]

64.
Ostergaard E, Duno M, Møller LB, Kalkanoglu-Sivri HS, Dursun A, Aliefendioglu D, Leth H, Dahl M, Christensen E, Wibrand F.
Novel Mutations in the PC Gene in Patients with Type B Pyruvate Carboxylase Deficiency.
JIMD Rep. 2013;9:1-5. doi: 10.1007/8904_2012_173. Epub 2012 Aug 31.

63.
Gourdon P, Sitsel O, Lykkegaard Karlsen J, Birk Møller L, Nissen P.
Structural models of the human copper P-type ATPases ATP7A and ATP7B.
Biol Chem. 2012 Apr;393(4):205-16. doi: 10.1515/hsz-2011-0249.

62.
Skjørringe T, Møller LB, Moos T.
Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders.
Front Pharmacol. 2012;3:169. doi: 10.3389/fphar.2012.00169. Epub 2012 Sep 25.

61.
Lenartowicz M, Krzeptowski W, Koteja P, Chrzascik K, Møller LB
Prenatal Treatment of Mosaic Mice (Atp7a mo-ms) Mouse Model for Menkes Disease, with Copper Combined by Dimethyldithiocarbamate (DMDTC).
PLoS One. 2012;7(7):e40400. Epub 2012 Jul 18

60.
Galve J, Vicente A, González-Enseñat MA, Pérez-Dueñas B, Cusí V, Møller LB, Julià M, Domínguez A, Ferrando J.
Neonatal erythroderma as a first manifestation of menkes disease.
Pediatrics. 2012 Jul;130(1):e239-42. Epub 2012 Jun 18

59.
Huppke P, Brendel C, Korenke GC, Marquardt I, Donsante A, Yi L, Hicks JD, Steinbach PJ, Wilson C, Elpeleg O, Møller LB, Christodoulou J, Kaler SG, Gärtner J.
Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase.
Hum Mutat. 2012 Apr 16. doi: 10.1002/humu.22099. [Epub ahead of print]

58.
Møller LB, Lenartowicz M, Zabot MT, Arnaud J, Burglen L, Bennett C, Riconda D, Janssens S, Fisher R, Mohammed S, Ausems M, Horn N, Jensen TG.
Clinical expression of Menkes disease in females with normal karyotype.
Orphanet J Rare Dis. 2012 Jan 22;7(1):6. [Epub ahead of print]

57. 
Huppke PM, Brendel C, Kahlscheuer V, Korenke G, Marquardt I, Freisinger P, Christodoulou J, Hillebrand M, Pitelet G, Wilson C, Gruber-Sedlmayr U, Ullmann R, Haas S, Elpeleg O, Nürnberg O, Nürnberg P, Dad S, Møller LB, Kaler S, Gärtner J.
Mutations in SLC33A1 cause a lethal autosomal recessive disorder with congenital cataracts and hearing loss associated with low serum copper and ceruloplasmin.
Am J Hum Genet. 90: 61-8 (2012)

56. 
Johannes Z, Thomas H, Møller LB.
Clinical utility gene card for: Phenylketonuria
Eur J Hum Genet  doi: 10.1038/ejhg.2011.172 (2012)

55. 
Mogensen M, Skjorringe T, Kodama H, Silver K, Horn N, Moller LB.
Exon duplications in the ATP7A gene: Frequency and Transcriptional Behaviour.
Orphanet J Rare Dis. 6: 73 (2011)
 
54. 
Møller LB, Hicks JD, Holmes CS, Goldstein DS, Brendl C, Huppke P, Kaler SG.
Diagnosis of Copper Transport Disorders.
Curr Protoc Hum Genet. Chapter 17: Unit17.9 (2011)

53. 
Gourdon P, Liu XY, Skjørringe T, Morth JP, Møller LB, Pedersen BP, Nissen P.
Crystal structure of a copper-transporting PIB-type ATPase.
Nature. 475:59-64 (2011)

52.
Møller LB, Horn N, Jeppesen TD, Vissing J, Wibrand F, Jennum P, Ott P.
Clinical presentation and mutations in Danish patients with Wilson Disease
Eur J Hum Genet. 19: 935-41 (2011)

51.
Skjørringe T, Tümer Z, Møller LB.
Splice site mutations in the ATP7A gene.
PLoS One. 6:e18599 (2011)

50. 
Poulsen L, Søe MJ, Møller LB, Dufva M.
Investigation of Parameters that Affect the Success Rate of Microarray-Based Allele-Specific Hybridization Assays.
PLoS One 6: e14777  (2011)
 
49.
Karam PE, Daher RT, Moller LB, Mikati MA.
Experience with hyperphenylalaninemia in a developing country: unusual clinical manifestations and a novel gene mutation.
J Child Neurol. 26: 142-6 (2011)
 
48. 
Dad S, Østergaard E, Thykjær T, Albrectsen A, Ravn K, Rosenberg T, Møller LB
"Identification of a novel   locus for a USH3 like syndrome combined with congenital cataract"
Clin Genet. 78: 388-97 (2010) 
 
47.
Reardon W, Donoghue V, Murphy AM, King MD, Mayne PD, Horn N, Birk Møller L.
Progressive cerebellar degenerative changes in the severe mental retardation syndrome caused by duplication of MECP2 and adjacent loci on Xq28.
Eur J Pediatr. 169: 941-949 (2010)
 
46.
Tümer Z, Møller LB.
Menkes disease.
Eur J Hum Genet. 18: 511-518 (2010)
 
45.
Møller LB, Mogensen M, Horn N.
Molecular diagnosis of Menkes disease: Genotype-phenotype correlation.
Biochimie.91: 1273-1277 (2009)
 
44.
Østergaard E, Møller LB, Kalkanoglu-Sivri HS, Dursun A, Kibaek M, Thelle T, Christensen E, Dunø M, Wibrand F.
Four novel PDHA1 mutations in pyruvate dehydrogenase deficiency.
J  Inherit Metab Dis. #173 (2009)
 
43.
Poulsen L, Søe MJ, Snakenborg D, Møller LB, Dufda M.
Multi-stringency wash of partially hypridized 60-mer probes reveals that the stringency along the probe decreases with distance from microarray surface.
Nucleic Acids Res 36: e162 (2008)
 
42.
Møller LB and Horn N.
Mutation detection in the Menkes gene ATP7A using the protein truncation test.
Clinical Medicine: Pathology 1: 1-5 (2008)
 
41.
Boycott KM, Parboosingh JS, Chodirker BN, Lowry RB, McLeod DR, Morris J, Greenberg CR, Chudley AE, Bernier FP, Midgley J, Møller LB and Innes AM.
Clinical genetics and the Hutterite population.
Am J Medical Genet. 146A:1088-1098 (2008)
 
40.
Birk Møller L, Nygren AO, Scott P, Hougaard P, Nielsen J, Hartmann C, Güttler F, Tyfield L and Zschocke J.
Low proportion of whole exon deletions causing phenylketonuria in Denmark and Germany.
Hum Mutat 28: (2007)
 
39.
Paulsen M, Lund C, Akram Z, Winther JR, Horn N and Møller LB.
Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites.
Am J Hum Genet. 79: 214-29 (2006)
 
38.
Roze E, Vidailhet M, Blau N, Møller LB, Doumma D, de Villemeu TB and Roubergue A.
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Movement Disorder 21: 263-266 (2006)
 
37.
Hertz JM, Østergaard K, Juncker I, Pedersen S, Romstad A, Møller LB, Güttler F and Dupont E.
Low frequency of  Parkin, Tyrosine Hydroxylase, and GTP Cyclohydrolase I gene mutations in a Danish population of early-onset Parkinson’s disease.
European Journal of Neurology 13: 385-390 (2006)
 
36.
Van Hove JLK, Steyaert J, Matthijs G, Legius E, Theys P, Wevers R , Romstad A, Møller LB, Hedrich K, Goriounov D, Blau N, Klein C and Casaer P.
Expanded motor and psychiatric phenotype in autosomal dominant Segawa syndrome due to GTP cyclohydrolase deficiency.
Journal of Neurology, Neurosurgery & Psychiatry 77: 18-23 (2006)
 
35. 
Korenke GC, Marquardt I, Moller LB, et al. Menkes' syndrome.
Clinical course during 2.5 years after initiating copper histidinate therapy in the 4th month life Monatsschrift kinderheilkunde 153: 864 (2005)
 
34. 
Møller LB, Ott P, Lund C, Horn N.
Homozygosity for a gross partial gene deletion of the C-terminal end of ATP7B in a Wilson patient with hepatic and no neurological Manifestations.
Am J Medical Genetics 138: 340-343 (2005)
 
33.
Møller LB, Paulsen M, Koch R, Moats R, Guldberg P and Güttler F.
Inter-individual variation in brain phenylalanine concentration in patients with PKU is not caused by genetic variation in the 4F2hc/LAT1 complex.
Molecular Genetics and Metabolism  Suppl 1: S119-23 (2005)
 
32.
Møller LB, Romstad A, Paulsen M, Hougaard P, Ormazabal A, Pineda M, Blau N, Güttler F and Artuch R.
Pre- and postnatal diagnosis of tyrosine hydroxylase deficiency.
Prenatal Diagn 25: 671-675 (2005)
 
31. 
Møller LB, Bukrinsky JT, Mølgaard A, Paulsen M, Lund C, Tümer Z, Larsen S and Horn N.
Identification and analysis of 21 novel disease-causing amino acid substitutions in the conserved part of ATP7A.
Hum Mutation 26: 84-93 (2005)
 
30. 
Kalkanoglu HS, Ahring K, Sertkaya D, Møller LB, Romstad A, Mikkelsen I, Guldberg P, Lou HC and Güttler F.
Behavioural effects of phenylalanine-free amino acid tablet supplementation in intellectually disabled adults with untreated phenylketonuria.
Acta Paediatrica 94: 1-5 (2005)
 
29. 
Horváth R, Freisinger P, Rubio R, Merl T, Bax R, Mayr JA, Shawan, Müller-Höcker J, Pongratz D, Møller LB, Horn N and Jaksch M. Congenital cataract, muscular hypotonia, developmental delay and sensorineural hearing loss: a new syndrome associated with a defect in copper metabolism? J Inheret Metab Disorders 28: 479-92 (2005)
 
28. 
Diepold K, Schütz B, Rostasy K, Wilken B, Hougaard P, Güttler F. Romstad A and Birk Møller L.
L-dopa responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections.
Movement Disorder 20: 764-767 (2005)
 
27. 
Poulsen L, Møller LB, Plunkett K, Belmont J, Tümer Z, Horn N.
X-linked Menkes disease: first documented report of germ-line mosaicism.
Genetic Testing 8: 286-291 (2004)
 
26.
Borm B, Møller LB, Hausser I, Emeis M, Baerlocher K, Horn N and Rossi R.
Variability in clinical courses in Menkes disease/Occipital horn syndrome despite identical mutation: observation of three affected males in one family.
J Pediatr 145: 119-21 (2004)
 
25. 
Matalon R, Koch R, Michals-Matalon K, Moseley K, Surendran S, Tyring S, Erlandsen H, Gamez A, Stevens RC, Romstad A, Møller LB and Güttler F.
Biopterin responsive phenylalanine hydroxylase deficiency.
Genet Med 6: 27-32 (2004)
 
24. 
Gérard-Blanluet M, Birk Møller L, Caubel I, Gélot A, de Villemeur B and Horn N.
Early development of occipital horns in a classical Menkes patient.
Am J Med Genet 130: 211-213 (2004)
 
23. 
Cerone R, Schiffinno MC, Fantasia AR, Perfumo M, Birk Møller L and Blau N.
Long-term follow-up of a patient with mild tetrahydrobiopterin-responsive phenylketonuria.
Molecular Genetics and Metabolism 81: 137-139 (2004)
 
22. 
Eschrich U, Preiß U, Brömme S, Jassoy A, Wohlrab J, Møller LB, Horn N and Burdach S.
Progression des Menkes-syndrom trotz normalisierung der kupfer- und caeruloplasminspiegel.
Monatsschrift Kinderheilkunde 11: 1233-1238 (2003)
 
21. 
Tümer Z, Birk Møller L and Horn N.
Screening of ATP7A deletions in 382 patients affected with Menkes disease
Hum Mut 22: 457-464 (2003)
 
20. 
Møller LB and Horn N. Copper uptake in Eukaryotic cells.
In Handbook of Copper Pharmacology and Toxicology, edited by Massaro EJ Humana Press 189-199 (2002)
 
19. 
Poulsen L, Horn N and Møller LB.
X-linked recessive Menkes disease: carrier detection in the case of a partial gene deletion.
Clin Genet, 62: 440-8 (2002)
 
18. 
Poulsen L, Horn N, Heilstup H, Lund C, Tumer Z and Møller LB.
X-linked recessive Menkes disease: identification of partial gene deletions in affected males.
Clin Genet 62: 449-57 (2002)
 
17. 
Petersen C, Møller LB and Valentin-Hansen P.
The cryptic adenine deaminase gene of Escherichia coli. Silencing by the nucleoid-associated DNA-binding protein, H-NS, and activation by insertion elements.
J Biol Chem 277: 31373-80 (2002)
 
16.
Seidel J, Møller LB, Mentzel H-J, Kauf E, VoigtS, Patzer S, Wollina U, Zintl F and Horn N.
Disturbed Copper Transport in Humans, Part 1: Mutations of the ATP7A gene lead to Menkes disease and Occipital horn syndrome.
Cell Mol Biol 47: 141-148 (2001)
 
15.
Petersen C and Møller LB.
The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation.
J Biol Chem 276:  884-94 (2001)
 
14. 
Petersen C and Møller LB.
Control of copper homeostasis in Escherichia coli by a P-type ATPase, CopA, and a transcriptional activator, CopR.
Gene 261: 289-298 (2000)
 
13. 
Møller LB, Petersen C, Lund C and Horn N.
Characterization of the hCTR1 gene: Genomic organization, functional expression, and identification of a highly homologous processed gene.
Gene 257:  13-22 (2000)
 
12. 
Møller LB, Tümer Z, Lund C, Petersen C, Cole T, Hanusch R, Seidel J, Jensen RL and Horn N.
Similar splicing mutations of the ATP7A gene lead to different phenotypes: Classical Menkes disease or Occipital horn syndrome.
Am J Hum Genet 66: 1211-1220 (2000)
 
11. 
Petersen C and Møller LB.
Invariance of the nucleoside triphosphate pools of Eschrichia coli with growth rate.
J Biol Chem 275: 3931-3935 begin_of_the_skype_highlighting (2000)
 
10. 
Jensen PY, Bonander N, Møller LB and Farver O.
Cooperative binding of copper(I) to the metal binding domains in Menkes disease protein. Biochem.
Biophys. Acta 1434: 103-113 (1999)
 
9. 
Tümer Z, Møller LB and Horn N.
Mutation spectrum of ATP7A, the gene defective in Menkes disease.
Adv Exp Med Biol 448: 83-95 (1999)
 
8. 
Nykjær A, Christensen EI,  Vorum H, Hager H, Petersen CM, Røigaard H, Min HY, Vilhardt F, Møller LB, Kornfeld S and Gliemann J.
Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction.
The Journal of Cell Biology 141: 815-828 (1998)
 
7. 
Blasi F, Conese M, Møller LB, Pedersen N, Cavallaro U, Cubellis MV, Fazioli F, Hernandezmarrero L, Limongi P, Munozcanoves P, Resnati M, Rittinen L, Sidenius N, Soravia E, Soria MR, Stoppelli MP, Talarico D, Teesalu T and Valcamonica S.
The urokinase receptor-structure, regulation and inhibitor-mediated internalization.
Fibronolysis 8: 182-188 (1994)
 
6. 
Møller LB, Pöllänen J, Rønne E, Pedersen N and Blasi F.
N-linked glycosylation of the ligand-binding damain of the human urokinase receptor contributes to the affinity for its ligand.
J Biol Chem 268: 11152-11159 (1993)
 
5. 
Møller LB.
Structure and function of the urokinase receptor.
Blood Coagulation & Fibrinolysis 4: 293-303 (1993)
 
4. 
Møller LB, Ploug M and Blasi F.
Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator.
Eur J Biochem 208: 493-500 (1992)
 
3. 
Pedersen N, Masucci MT, Møller LB and Blasi F.
A non-catalytic, human urokinase plasminogen activator derivate produced by mouse cells has full receptor binding activity.
Fibrinolysis 5: 155-164 (1991)
 
2. 
Møller LB, Kaufman J, Verland S, Salomonsen J, Avila D, Lambris JD and Skjødt K.
Variations in the cytoplasmic region account for the heterogeneity of the chicken MHC class I (B-F) molecules.
Immunogenetics 34: 110-120 (1991)
 
1. 
Blasi F, Behrendt N, Cubellis MV, Ellis V, Lund LR, Masucci MT, Møller LB, Olson DP, Pedersen N, Plough M, Rønne E and Danø K.
The urokinase receptor and regulation of cell surface plasminogen activation.
Cell Differentiation and Development 32: 247-254 (1990)